What KPV is
KPV is a tiny peptide of just three amino acids: lysine, proline, and valine. It is the tail end of alpha-MSH, a hormone that, among other things, calms inflammation.
Interest in KPV comes mostly from animal studies of inflammatory bowel disease and skin inflammation. It is also the fourth ingredient in the KLOW blend.
Regulatory status in 2026
KPV is not an approved drug and is not on the list of substances pharmacies may compound from. It went through the same 2026 review as BPC-157.
KPV is one of 12 peptides removed from FDA's Category 2 list. Removal does not make it legal to compound.
FDA's advisory committee votes 8 to 6, with one abstention, to recommend adding KPV to the compounding list. FDA staff had proposed not adding it.
FDA has not added KPV to the compounding list.
Regulatory status can change. Check the sources linked at the bottom of this page before relying on anything here.
Claims vs. what the research shows
KPV's evidence is almost entirely from cell and animal studies.
Calms gut inflammation.
Reduces inflammation in mouse models of colitis. No published human trials.
Animal or limited evidenceClears inflammatory skin conditions.
Early lab and animal data only.
Animal or limited evidenceSafe because it's a natural fragment.
Not established. There is no human safety data for injected KPV.
Insufficient dataStorage and stability
Peptides break down with heat, light, moisture, and repeated freezing and thawing. Degraded product is one common reason two vials of the "same" peptide behave differently. These are general peptide handling practices. Your supplier's certificate of analysis or label takes priority.
Sealed powder (lyophilized)
- Refrigerate at 36 to 46°F (2 to 8°C) for routine storage.
- Freezer is generally used for long-term storage.
- Keep in its original sealed vial, away from light.
- Let a cold vial reach room temperature before opening to limit condensation.
After reconstitution
- Keep refrigerated. Do not freeze.
- Protect from light. Clear glass lets it through.
- Opened multi-dose bacteriostatic water is typically discarded 28 days after first puncture.
- Log the mix date so you know the vial's age at a glance.
Light exposure is easy to overlook in a fridge door that opens dozens of times a day. VIALTIGHT is building stackable cases that block light from every side. See vialtight.com for updates.
Reconstitution math
Concentration is just the amount of peptide divided by the volume of water added. On a U-100 insulin syringe, 100 units equals 1 mL, so each unit is 0.01 mL. Enter what is on your vial label and what you added to see the concentration.
This shows concentration only. It is not a dosing recommendation. VialTracker runs this math for every vial you log and keeps it with the vial's history.
Safety flags
Product quality is unverified. Gray-market vials have been found underdosed, mislabeled, or contaminated. A certificate of analysis from the seller is not the same as independent testing.
Human safety is unknown. No published human safety data exists for injected or oral KPV.
Blends hide amounts. KPV is often sold inside blends like KLOW, where the actual amount may not be listed.
FAQ
Is KPV legal?
It is not FDA-approved and not on the compounding list, so it cannot be legally marketed for human use.
Did FDA approve KPV in 2026?
No. An advisory committee recommended adding it to the compounding list. That is not approval, and FDA has not acted on it.
Does VialTracker tell me what to take?
No. VialTracker organizes the information you enter and runs the math. It does not recommend doses, products, or protocols.